Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway
收藏干细胞与再生医学数据中心2021-12-14 更新2024-03-06 收录
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Neurogenesis was increased during early neural stem cell differentiation with two opioids, morphine and naloxone. In contrast, the membrane-impermeable analogue of naloxone, methiodinated naloxone, had no effect on neural stem cell differentiation. A similar phenomenon was observed for the ability of morphine and naloxone to promote neurogenesis in opioid receptor knockout neural stem cells. Thus, morphine and naloxone promote neurogenesis in a receptor-independent manner early on. To verify this, samples from the early stages of differentiation were sequenced by adding different reagents
提供机构：
中国科学院广州生物医学与健康研究所
创建时间：
2021-12-14
