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H3K4 methylation orchestrates epigenome of oocytes

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NIAID Data Ecosystem2026-05-10 收录
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How H3K4 methylation regulates oocyte development is largely unexplored. In this study, we demonstrate that oocyte-specific expression of dominant negative mutant H3.3-K4M led to decrease of the level of H3K4 methylation and reduced global transcriptional activity in mouse oocytes, leading to disturbed oocyte developmental potency.

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2025-12-01
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