A DNA methylation database of human and mouse hematological malignancy cell lines. A DNA methylation database of human and mouse hematological malignancy cell lines

Human cancer cell lines constitute useful models to model the primary disease and many relevant findings in tumor biology have been originated from them since the first immortalized cell line (HeLa) was obtained. The easy experimental intervention, the purity of the transformed cells and their versatility to undergo high-throughput screenings represent advantageous features of the established cancer cell lines. Herein, we have obtained the DNA methylation profiles of 210 cell lines derived from hematological malignancies utilizing comprehensive DNA methylation microarrays that interrogate more than 850,000 and 285,000 CpG sites from human and mouse genomes, respectively. Overall design: Bisulphite converted DNA from 210 hematological cell lines, 180 from human and 30 from mouse were hybridized to the Illumina Infinium HumanMethylationEPIC version 1.0 microarray and Infinium Mouse Methylation BeadChip, respectively.