TRPV3

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

该基因产物隶属于一类非选择性阳离子通道家族，该家族在多种生理过程中发挥作用，包括温度感知和血管调节。该家族中具有温度敏感性的成员表达于皮肤终止的感觉神经元亚群中，并在特定的生理温度下被激活。该通道在22至40摄氏度的温度范围内被激活。该基因与位于第17号染色体上的另一家族成员基因紧密相邻，并且认为这两种编码的蛋白质相互结合，形成异源二聚体通道。对于该基因，已发现多种转录变体，它们编码不同的同源异构体。[由RefSeq提供，2012年4月]