Transcription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients

ChEBI2009-09-05 更新2026-07-21 收录

阿尔茨海默病机制

神经细胞转录组学

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-4757 数据链接链接失效反馈

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Transcription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients

创建时间：

2009-09-05

The CD33 short isoform is a gain-of-function variant that enhances Aß1-42 phagocytosis in microglia I. The CD33 short isoform is a gain-of-function variant that enhances Aß1-42 phagocytosis in microglia I

阿尔茨海默病机制

小胶质细胞吞噬功能

Background: CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferent

NIAID Data Ecosystem30

RNA sequencing data of leptomeningeal/perivascular CAMs 8 weeks after repopulation.

中枢神经系统巨噬细胞再殖

神经细胞转录组学

Perivascular and leptomeningeal macrophages are non-parenchymal macrophages summarized as central nervous system (CNS)-associated macrophages (CAMs) that mediate immune responses at brain boundaries.

NIAID Data Ecosystem00

Data_Sheet_6_Suppression of hnRNP A1 binding to HK1 RNA leads to glycolytic dysfunction in Alzheimer’s disease models.zip

阿尔茨海默病机制

糖酵解调控

ObjectiveTo investigate the mechanism of RNA-binding protein hnRNP A1 in mouse hippocampal neurons (HT22) on glycolysis. MethodsRIP and CLIP-qPCR were performed by HT22 in vitro to observe the mechani

NIAID Data Ecosystem00

Data Sheet 1_Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model.docx

阿尔茨海默病机制

饮食诱导神经炎症

IntroductionWestern diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal white adipose tissue (eWAT), a representa

NIAID Data Ecosystem00

Lysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction

阿尔茨海默病机制

溶酶体蛋白质组学

The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abn

NIAID Data Ecosystem00

Transcription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients

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