Evaluation of metabolomic changes in serum and intestinal content of morbidly obese patients subjected to bariatric intervention - part 2 Aminoacids analysis

<p class="MsoNormal">Obesity, a major health condition in the modern world, poses
numerous health risks and can reduce life expectancy by 8 to 10 years. The most
effective treatment for obesity remains bariatric surgery, which results in
significant weight loss and improved metabolism. Currently, few surgical
techniques are performed, and the choice of the procedure is dependent on the
age of the patient, the presence and severity of co-morbidities, and the BMI.
Some of the most commonly performed bariatric procedures are laparoscopic
sleeve gastrectomy (LSG) and one anastomosis gastric bypass (OAGB). Both
techniques are effective in inducing weight loss and improving markers of
obesity-related diseases, as well as overall quality of life. Although the
clinical outcomes and differences between bariatric procedures are well
established, data on procedure-specific metabolic alterations remain limited. The
analysis of amino acid profiles in bariatric surgery patients is a cornerstone
of long-term metabolic and nutritional monitoring. Surgical alterations to the
gastrointestinal tract significantly impact protein digestion and absorption,
often leading to specific deficiencies in both essential and non-essential
amino acids. This assessment is particularly critical for preserving lean body
mass, which is a primary determinant of a healthy resting metabolic rate.
Understanding post-operative shifts in amino acid concentrations enables the
personalization of medical nutrition therapy, ensuring optimal recovery and
preventing complications related to qualitative malnutrition.</p>