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Neuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]

ChEBI2014-03-12 更新2026-07-21 收录

骨髓增殖性肿瘤

造血干细胞微环境

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-55798 数据链接链接失效反馈

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Neuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]

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创建时间：

2014-03-12

造血干细胞微环境

滑膜与骨膜细胞基因表达

A subset of osteoblasts functions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on

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Physical interaction between mutant calreticulin and the thrombopoietin receptor is required for transformation of hematopoietic cells. Mus musculus

骨髓增殖性肿瘤

癌症信号通路

Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). However, the mechanism by which mutant CALR is oncogenic is unknown. Here

NIAID Data Ecosystem70

RNA-seq analysis of bone marrow peri-vascular stromal cells. Mus musculus

造血干细胞微环境

周血管基质细胞转录组

Fate decisions of haematopoietic stem cells (HSCs) to self-renew or differentiate in response to various demands are finely tuned by specialized microenvironments called “niches” in the bone marrow. R

NIAID Data Ecosystem50

Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner. Mus musculus

造血干细胞微环境

转录因子调控

Hematopoiesis requires the interaction of hematopoietic stem cells (HSCs) with various stromal microenvironments. Here, we examine the role of early B cell factor 2 (Ebf2), a transcription factor expr

NIAID Data Ecosystem80

Sequencing_of_JAK2V617F_MPN_Mouse_tumours. Sequencing_of_JAK2V617F_MPN_Mouse_tumours

骨髓增殖性肿瘤

体细胞突变测序分析

A gain-of-function JAK2V617F mutation is found in the vast majority of patients with polycythemia vera (PV) and in 50-60% of those with essential thrombocythemia (ET) or idiopathic myelofibrosis (IMF)

NIAID Data Ecosystem70

Neuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]

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