Mutation, antiviral activity, and surface exposure of residues of the huAPOBEC3G N-CDA.

Novel functional residues that abolish huAPOBEC3G antiviral activity against wild-type HIV-1 infection are highlighted bold. *0 = no activity, +residual activity (<10% of wild type),++modest activity (10–50%), +++full activity. **Semiquantitative western blot ***Estimated by side chain+backbone. Values greater than 20 suggest that the residue is exposed at the surface.