Proteomic landscape of cholangiocarcinomas reveals 3 different subgroups according to their localization and the underlying non-tumor liver

Cholangiocarcinomas (CC) define a heterogeneous entity based upon their anatomic localization along the biliary tree and, for those developing in the liver (iCC), depending on the aspect of non tumoral liver (cirrhosis or not). Gene expression analysis of iCC revealed 2 main subgroups (inflammatory and proliferative). The aim of the study was to address the heterogeneity of CC by comparing their protein expression using a global quantitative proteomic approach.