Characteristics, completion and publication of PROSPERO records in regional anesthesia for acute perioperative pain: supplementary data

Aim: We analyzed characteristics and completion status of Systematic Reviews (SRs) about regional
anesthesia for acute perioperative pain relief registered in PROSPERO. Materials & methods: PROSPERO
was searched on 5 January 2022. Characteristics of PROSPERO records, completion status and publication
information were extracted. PubMed and Google Scholar were searched by 31 May 2022, for additional
published SRs. The inconsistency of PROSPERO records’ status was analyzed by comparing the most
recent PROSPERO statuswith subsequent publication of completed SR. Time-to-publication was calculated.
Results: Almost half of 174 included PROSPERO records (49%) were registered in 2021. A median of 3
(IQR: 2–4.75) authors, and a search of 4 information sources (IQR: 3–5) was planned. At first registration,
51 (29%) records had already started or completed formal screening. PROSPERO records included mostly
adults (48%) undergoing trunk blocks (56%), with pain intensity (74%) as a main outcome. 147 (84%)
PROSPERO records had a status “ongoing”. Yet, 71 (41%) PROSPERO records were completed SRs, published
after a median of 291 days. Inconsistency in status was found in 34% of PROSPERO records. Conclusion:
Despite an increase in PROSPERO registrations about regional anesthesia, most were not published, and
a third had inaccurate status.

目标：本研究旨在分析注册于PROSPERO平台关于区域麻醉用于急性围手术期疼痛缓解的系统评价（SRs）的特征及完成情况。研究方法：于2022年1月5日对PROSPERO进行了检索。提取了PROSPERO记录的特征、完成状态及出版信息。至2022年5月31日，通过PubMed和Google Scholar检索了额外的已发表的系统评价。通过比较最新的PROSPERO状态与已完成SR的后续出版物，分析了PROSPERO记录状态的矛盾性。计算了出版时间。结果：在174条纳入的PROSPERO记录中，近一半（49%）于2021年注册。平均作者人数为3名（中位数：3，四分位数范围：2-4.75），计划搜索4个信息来源（四分位数范围：3-5）。在首次注册时，已有51条记录（29%）开始或完成了正式筛选。PROSPERO记录主要涉及成年人（48%），接受躯干阻滞（56%），疼痛强度（74%）为主要结局指标。147条（84%）PROSPERO记录状态为“进行中”。然而，71条（41%）PROSPERO记录为已完成SR，并于平均291天后发表。在34%的PROSPERO记录中发现了状态的不一致性。结论：尽管关于区域麻醉的PROSPERO注册数量有所增加，但大多数尚未发表，且有三分之一的状态不准确。