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a-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

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NIAID Data Ecosystem2026-05-17 收录
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We conducted gene expression analysis of naive and polarized macrophages from wild type C57BL6/J mice. In this project, we also compared how glutamine deprivation and production of alpha-ketoglutarate during LPS priming affects gene expression profiles in bone marrow-derived macrophages. Overall design: Find unbiased transcriptomic changes affected by glutamine metabolism in endotoxin tolerant macrophage

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2017-09-17
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