Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice
收藏Figshare2016-10-07 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/Cell_Active_Hydroxylactam_Inhibitors_of_Human_Lactate_Dehydrogenase_with_Oral_Bioavailability_in_Mice/3807315
下载链接
链接失效反馈官方服务：
资源简介：
A series of trisubstituted hydroxylactams was identified as potent enzymatic and cellular inhibitors of human lactate dehydrogenase A. Utilizing structure-based design and physical property optimization, multiple inhibitors were discovered with 50 in a MiaPaca2 cell line. Optimization of the series led to 29, a potent cell active molecule (MiaPaca2 IC50 = 0.67 μM) that also possessed good exposure when dosed orally to mice.
创建时间：
2016-10-07
