The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells [seq]
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https://www.ncbi.nlm.nih.gov/sra/SRP057264
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资源简介：
Using an unbiased chemical biology approach, we discover harmine as a novel regulator of Treg/Th17 differentiation. Harmine enhances Treg differentiation (working in conjunction with low levels of exogenous TGFb) and inhibits Th17 differentiation. Analysis of global gene expression of Tregs generated using low TGFb + harmine reveals significant similarity to Tregs generated using high TGFb only and suggests relevance of harmine-engaged mechanisms to IBD. Overall design: Naïve murine CD4+CD62L+ T cells were stimulated with anti-CD3/28, transduced with control or Dyrk1a shRNA, and treated with harmine or control.
创建时间：
2017-09-17
