Physiochemical and ADME data.

For microsomal stability, verapamil was used as a high-metabolism control (0.24% remaining with NADPH) and warfarin was a low-metabolism control (85% remaining with NADPH). The kinetic solubility limit was the highest concentration with no detectable precipitate. For Caco-2 cell permeability, compounds at a concentration of 10 μM were incubated for 2 h. Papp = apparent permeability coefficient. All compounds showed poor recovery due to either low solubility or non-specific binding. Ranitidine, warfarin and talindol were used as low permeability, high permeability and P-gp efflux, controls respectively.