CDK2-CyclinE1 in complex with allosteric inhibitor I-198.
收藏Protein Data Bank Japan2025-03-12 更新2026-04-19 收录
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CDK2-CyclinE1 in complex with allosteric inhibitor I-198. Descriptor: (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 Authors: Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. Deposit date: 2024-01-17 Release date: 2024-01-31 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (1.84 Å) Cite: An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes. Nat.Chem.Biol., 21, 2025
创建时间：
2024-01-17
