Combination of mTOR and JAK2 inhibitor resulted synergistic in reducing erythropoietin-independent colony formation in primary cells from PV patients.

Data shown (mean ± SD) are derived from the analysis of two patients, in duplicate. The Combination Index (CI) was calculated as described in Materials and Methods. A CI<1 indicates that the interaction of the two drugs is synergistic. The first two columns (in gray) report, for convenience, the IC50 value of the individual drugs in this experimental setting (see Results section for details).