Stem cells may play a role in the development and maintenance of proliferative diseases of the prostate such as prostate cancer and benign prostatic hyperplasia. Cell membrane protein markers, CD49f,

NIAID Data Ecosystem20

Expression profile from murine acute myeloid leukemia cells C1498 with or without PARP-1 inhibition. Mus musculus

基因表达

急性髓系白血病

Poly(ADP-ribose) polymerase 1 (PARP-1) is abnormally expressed in a wide variety of tumors. Emerging evidence suggests that PARP-1 plays key roles in multiple biologic behaviors of tumors, such as mod

NIAID Data Ecosystem40

The novel BETi BI 894999 represses super-enhancer associated transcription and synergizes with CDK9 inhibition in AML by induction of apoptosis

急性髓系白血病

表观遗传学

Bromodomain and extra-terminal (BET) protein inhibitors have been reported as treatment options for acute myeloid leukemia (AML) in preclinical models and are currently being evaluated in clinical tri

NIAID Data Ecosystem30

CD200 expression marks leukemia stem cell (LSC) in human AML

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