Enantioselective Total Synthesis of (+)-Sieboldine A
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https://figshare.com/articles/dataset/Enantioselective_Total_Synthesis_of_-Sieboldine_A/4633279
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资源简介：
The first total synthesis of (+)-sieboldine
A was completed starting
from 5-(p-methoxybenzyloxy)pentyne in 19 steps. The
enantioselective Keck allylation provided the dienyne derivative,
which was exposed to the Pauson–Khand conditions to afford
the bicyclo[4.3.0]nonenone derivative with high stereoselectivity
with an ee value of 93%. The following Ueno–Stork reaction
formed the cis-hydrindane core with a quaternary
carbon center. The late-stage Schmidt glycosylation led to the formation
of the N-hydroxyazacyclononane ring.
创建时间：
2017-02-08
