Structure of KIT V654A mutant with Compound 1

Structure of KIT V654A mutant with Compound 1 Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Mast/stem cell growth factor receptor, N~2~-methyl-N~4~-{(5P)-5-(1-methyl-1H-pyrazol-4-yl)-4-[(propan-2-yl)oxy]pyridin-2-yl}pyrimidine-2,4-diamine Authors: Kim, J.L. Deposit date: 2025-11-04 Release date: 2026-03-18 Last modified: 2026-05-06 Method: X-RAY DIFFRACTION (1.543 Å) Cite: Design and Synthesis of BLU-654, a Potent and Selective Mutant KIT V654A Inhibitor for the Treatment of Imatinib-Resistant GIST. J.Med.Chem., 69, 2026