Raw Data on Extracellular Particles in 613 Human and 163 Canine Diluted Plasma and Blood Samples Assessed by Interferometric Light Microscopy

Extracellular nanoparticles (EPs) are cellular fragments. After being released in cell exterior, they become  mediators of the cell-cell interaction. Their characterization in bodily fluids may reflect the clinical status of the organism. Here we present data on the number density n and hydrodynamic diameter Dh of EPs assessed directly in diluted plasma and blood by using a recently developed technique, Interferometric Light Microscopy  (Romolo et al., 2022). The data are presented in the attached Table.

We collected 613 blood and plasma samples from human patients with Inflammatory Bowel Disease (IBD) taken into tubes with trisodium citrate and ethylenediaminetetraacetic acid (EDTA) anticoagulants and 163 blood and plasma samples from canine patients with Brachycephalic Obstructive Airway Syndrome (BOAS). The human study was conducted in accordance with the Declaration of Helsinki, and approved by the National Medical Ethics Committee of the Republic of Slovenia (0120-271/2022/4; KME 27 July 2022). All procedures in the animal study complied with the relevant Slovenian government regulations (Animal Protection Act, Official Gazette of the Republic of Slovenia, No. 43/2007). The animal study was approved by the Animals in Experiments Welfare Commission of the Veterinary Faculty, University of Ljubljana, approval number 18-3/2022-1. Information regarding sample preparation is documented in the MIBlood-EV reports.