File S1 - Identification of a Novel Function of CX-4945 as a Splicing Regulator

Supporting information file containing Figures S1 to S7 and Table S1. Figure S1. Effect of CX-4945 on CK2 α′ mRNA levels. Figure S2. The effect of CX-4945 on normal alternative splicings of Bcl-X, RON, and Clk1/Sty. Figure S3. Identification of an extra PCR product of QRSL1 mRNA. Figure S4. The siRNA-mediated knockdown of the catalytic subunits of CK2, CK2α and CK2α′, does not affect alternative splicing. Figure S5. CX-4945 modulates SR protein phosphorylation in a CK2-independent manner. Figure S6. The inhibitory activities of CX-4945 on Clks were stronger than those of TG-003. Figure S7. CX-4945 induced the expression of gluconeogenic genes in HepG2 cells. Table S1. Primer sequences used in quantitative RT-PCR. (DOCX)