Cis-xQTLs, Colocalization results, xTWAS weights, and xTWAS results from bulk RNA-seq data of ROS/MAP DLPFC tissue

This repository contains cis-xQTL mapping results, colocalization analysis results, and transcriptome-wide association study (xTWAS) weights and association test statistics for six transcriptomic modalities generated from bulk RNA-seq data of dorsolateral prefrontal cortex (DLPFC) tissue from the ROS/MAP cohorts (n = 1,035). The RNA trait tables (BED format) used for cis-xQTL mapping and xTWAS model training were generated using the Pantry pipeline but are not included in this repository. Colocalization and xTWAS analyses were performed using the publicly available Alzheimer’s disease (AD) dementia GWAS summary statistics from Bellenguez et al. (Nature Genetics, 2022).