CeRNA Microarray-Based Identification of Specific LncRNA Markers in Severe Tuberculosis for Early Diagnosis

Tuberculosis (TB) is still one of the leading causes of death from a single infectious agent in the world.The progression of tuberculosis to severe disease is the main cause of death of tuberculosis patients. Early identification of severe tuberculosis is very important. LncRNA can be used as a potential marker in the diagnosis of tuberculosis, but there is a lack of research on lncRNA in the field of severe tuberculosis.This study aims to use CeRNA Microarray analysis to identify specific lncRNAs as potential biomarkers for severe tuberculosis diagnosis. Genome-wide lncRNA profiling of peripheral blood mononuclear cells (PBMCs) from severe tuberculosis (STB) patients, mild tuberculosis patients (MTB), and healthy controls (HCs) was conducted using the Agilent microarray technique. STB:8 samples;MTB:12 samples;HC:10 samples