Effect of GDNF-transfected macrophages on inflammation and neurodegeneration in mice with PD modela.

aBALB/c mice were i.c. injected with 6-OHDA. Forty eight hours later, the animals were i.v. injected with various macrophage-based formulations or PBS. A control group was i.c. injected with PBS, and then 48 hours later i.v. injected with PBS.bTotal number of neurons was calculated in ipsilateral hemisphere.cStatistical significance is shown by asterisk: ppi.c. PBS injections followed by i.v. PBS injections (healthy controls); or pi.c. 6-OHDA injections followed by i.v. PBS injections (PD controls). Errors are mean ±SEM, N = 7.Effect of GDNF-transfected macrophages on inflammation and neurodegeneration in mice with PD modela.