Serum Proteomic characterization in Stump-tailed macaque (Macaca arctoides) with neutralizing antibodies against Dengue virus in Thailand

The dengue virus (DENV) is a leading public health problem world wide which transmitted by mosquito in the genus Ades. DENV is a single positive-stranded RNA virus with four serotypes, including DENV1-4. Infection with each serotype may provide lifelong immunity. However, reinfection with different serotypes promotes more severe disease symptoms from antibody-dependent enhancement (ADE). DENV causes a wide spectrum of clinical manifestations in humans including asymptomatic or mild dengue fever (DF), life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In Southeast Asia, the increasing transmission of zoonotic diseases from animals to humans, particularly in non-human primates (NHPs), presents a significant and concerning trend. NHPs play an important role as a reservoirs of DENV transmission. In our study, the serum of wild macaques with and without neutralizing antibodies against DENV was separated to profile the proteome using proteomics and bioinformatics techniques.