Single nuclei RNA-seq of brain of mouse Alzheimer's disease model

Here we report single nucleus RNA-seq shows in 5xFAD mouse model of AD and WT, showing changes in the composition and state of multiple cell types. In particular, we identified a unique population of disease-associated astrocytes (DAAs) in AD. DAAs appeared at early disease stages and increased in abundance with age. Similar cells were found in aged WT mice and human brains, suggesting they are linked to both genetic and age-related factors. Overall design: Single nuclei RNA-seq of WT and 5xFAD mouse brains, from hippocampus brain region