Ni-Catalyzed Enantioselective C‑Acylation of α‑Substituted Lactams
收藏Figshare2016-07-21 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Ni-Catalyzed_Enantioselective_i_C_i_Acylation_of_Substituted_Lactams/3487877
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资源简介：
A new strategy for catalytic enantioselective C-acylation to generate α-quaternary-substituted lactams is reported. Ni-catalyzed three-component coupling of lactam enolates, benzonitriles, and aryl halides produces β-imino lactams that then afford β-keto lactams by acid hydrolysis. Use of a readily available Mandyphos-type ligand and addition of LiBr enable the construction of quaternary stereocenters on α-substituted lactams to form β-keto lactams in up to 94% ee.
创建时间：
2016-07-21
