Depletion of CRAT in cardiomyocyte results in DCM

Carnitine acetyltransferase (CRAT) is a mitochondrial enzyme and catalyzes the conversion of acetyl-CoA to acetyl-Carnitine, which enables its export from mitochondria. It was reported that CRAT played a central role in regulating metabolic flexibility and promoting substrate switching from fatty acid to glucose in skeletal myocytes5. Interestingly, CRAT is most abundantly expressed in the heart and its activity is dramatically decreased in the mouse model of HF5,9. However, the specific contribution of this enzyme in the pathogenesis of HF remains largely uncharacterized.肉碱乙酰转移酶（Carnitine acetyltransferase，CRAT）是一种线粒体酶，可催化乙酰辅酶A转化为乙酰肉碱，该产物可从线粒体中被转运出去。已有研究表明，CRAT在调控代谢灵活性以及促进骨骼肌细胞中底物从脂肪酸向葡萄糖转换的过程中发挥核心作用5。值得注意的是，CRAT在心脏组织中表达丰度最高，且在心力衰竭（Heart Failure，HF）小鼠模型中其活性会显著降低5,9。然而，该酶在心力衰竭发病机制中的具体贡献仍未得到充分阐明。