Decoding the Brain Mosaic: Region and Cell Type-Specific Dysregulation Patterns in Stress and Psychiatric Disorders

Supplementary Online Tables for the doctoral thesis "Decoding the Brain Mosaic: Region and Cell Type-Specific Dysregulation Patterns in Stress and Psychiatric Disorders" by Nathalie Gerstner. This repository includes complete lists of differentially expressed and differential hub genes, alongside the results of enrichment analysis for 8 brain regions examined in a mouse model for transcriptomic alterations following glucocorticoid stimulation (Online Tables 1-30). Additionally, the repository encompasses the complete results of differential expression and chromatin accessibility analyses across various cell types examined in postmortem brain tissue of the orbitofrontal cortex (Online Tables 31-37). These findings delineate the transcriptomic and epigenomic changes between psychiatric cases and controls, as well as between donors with high and low genetic risk for psychiatric disorders. The lists of all genes tested in the respective studies, not just the significant ones, can be found in the "GRactivation_MouseBrain_tables.zip" and the "SingleNuc_PostmortemBrain_Tables.zip" archives.