Nociceptor neurons affect cancer immunosurveillance [RNA-seq 3]

Sequecing tumor-innervating neurons Naive DRG neurons (TRPV1cre::QuASR2-eGFPfl/wt) were cultured alone or in combination with B16F10-mCherry-OVA. After 48h, the cells were harvested, FACS-purified, and RNA sequenced. Hierarchical clustering of sorted neuron DEG, show distinct groups of transcripts enriched in TRPV1+ neuron vs cancer-exposed TRPV1+ neuron populations. Pairwise comparison of naive TRPV1+ neuron vs cancer-exposed TRPV1+ neuron populations showing differentially expressed transcripts as a volcano plot.