Data from: RNA sequencing of rabbit placentas exposed to a PFAS-mixture

<strong>*Data will be embargoed until publication of related article, or up to no more than 1 year from data upload.*</strong>

A mixture of per and polyfluoroalkyl substances (PFAS) are found in drinking water, diet, and household dust. These environmental contaminants are detected in up to 99% of human serum samples; yet very little is known about how exposures to exposure to mixtures of these compounds affect maternal and fetal health during pregnancy. We investigated the maternal, fetal, and placental outcomes after maternal exposure to an environmentally relevant PFAS-mixture during pregnancy in a New Zealand White (NZW) rabbit model. Female NZW rabbits were supplied control (no detectable PFAS levels) or PFAS-contaminated drinking water, which was formulated with PFAS to resemble levels measured in tap water collected from Pittsboro, NC (10 PFAS compounds; total PFAS load = 758.6 ng/L). Maternal, fetal, and placental outcomes were evaluated at necropsy. Further, dysregulated gene expression in the placenta was determined by RNA sequencing. 14 genes (p<0.1) were identified as significantly different, 9 of which are associated with adverse placental function related to pregnancy complications.