Dopa decarboxylase activity of the living human brain.
收藏PubMed Central1991-04-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC51310/
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资源简介：
Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculated the enzyme activity, relative to its Km, with a kinetic model that yielded the relative rate of conversion of 6-[18F]fluoro-L-dopa to [18F]fluorodopamine. Regional values of relative dopa decarboxylase activity ranged from nil in occipital cortex to 1.9 h-1 in caudate nucleus and putamen, in agreement with values obtained in vitro. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-04-01
