The Demographic Profile of Colorectal Cancer Patients in Indonesia: Insights from a Single Center Experience and Exploration of Immune Response and Survival Outcomes

Understanding the demographics of CRC patients is crucial for identifying high-risk individuals and customizing screening and prevention strategies. Furthermore, delving into histopathology, tumor staging, location, and metastasis presence offers valuable insights for treatment planning and prognosis in CRC cases. Additionally, investigating genetic mutations like KRAS, NRAS, and BRAF is essential for guiding targeted therapy administration, predicting treatment responses, and determining prognosis. Assessing the prevalence of Microsatellite Instability-High (MSI-H)/Deficient Mismatch Repair (dMMR) or Microsatellite Stable (MSS)/Proficient Mismatch Repair (pMMR) is crucial for predicting responses to immunotherapy and prognosis. Understanding the percentage of patients receiving surgical treatment, targeted therapy, chemotherapy, and immunotherapy is essential for identifying areas where therapeutic approaches can be improved. The objective of this study is to investigate the demographic and clinical characteristics of CRC patients, including age, sex, BMI, comorbidities, tumor location, tumor side, KRAS, NRAS, and BRAF mutation status, microsatellite instability, immune score, disease stage, metastasis presence, and targeted therapy use. Additionally, the study aims to investigate the relationship between patient characteristics and immune score, as well as patient characteristics and survival.