EOG recordings and cookie-finding tests after intranasal (IN) MPTP application.

(A) Olfactory epithelium after intranasal application of 5 µl blue dye. EOGs were measured in the indicated areas of the OE. (B) EOG data from mice treated wit 0.5 mg/nostril MPTP intranasally. The amplitude was significantly reduced in MPTP treated wildtype (p<0.01), and BAsyn animals (p<0.05), while the rise and the decay time of the responses did not differ (nMPTP = 6, nsaline = 10). (C) After the training day (day 4), wildtype mice treated IN with MPTP treated took significantly longer to find the cookie 5 days (p<0.01) and 6 days (p<0.05) after MPTP application (n = 10 for each condition), compared to control animals. Finding time of BAsyn mice was not increased after IN MPTP treatment. (D) Animal mobility (mean movement velocity) during the cookie-finding test. Data is normalized to the wild type animals. No significant difference was detectable between saline and MPTP treated animals. BAsyn mice display a significantly reduced mobility (p<0.01). Error bars represent SEM.