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Studies Directed toward Asymmetric Synthesis of Cardioactive Steroids via Anionic Polycyclization

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https://figshare.com/articles/dataset/Studies_Directed_toward_Asymmetric_Synthesis_of_Cardioactive_Steroids_via_Anionic_Polycyclization/3744975
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The use of anionic polycyclization (AP) in constructing the steroidal backbone of cardenolides was investigated. The reaction of 2-carbomethoxy-2-cyclohexenone I with the enolate of Nazarov reagent II gave, after decarboxylation and aldol condensation, steroid III with control of stereochemistry.
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2016-08-20
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