SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7

SOCS1 and SOCS3 recruit Elongin B (ELOB), Elongin C (ELOC), Cullin5 (CUL5), and RNF7 to CSF3R to form a ubiquitin E3 ligase complex (Kamura et al. 2004 and inferred from mouse homologs). SOCS3 has 100-fold higher affinity for CUL5 than SOCS1 has (inferred from mouse homologs).

SOCS1与SOCS3能够招募Elongin B（ELOB）、Elongin C（ELOC）、Cullin5（CUL5）和RNF7至CSF3R，进而形成一种泛素化E3连接酶复合物（参见Kamura等人的研究，2004年，并基于小鼠同源基因推断）。据小鼠同源基因推断，SOCS3对CUL5的亲和力比SOCS1高出百倍。