Supplementary materials: Healthcare utilization and costs among patients with acromegaly in the United States

These are peer-reviewed supplementary materials for the article 'Healthcare utilization and costs among patients with acromegaly in the United States' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: List of CPT and ICD Codes for Hypophysectomy and Stereotactic RadiosurgerySupplementary Table 2: List of ICD Codes for Specific Comorbidities of InterestSupplementary Table 3: List of CPT and ICD Codes for Radiation TherapyAim: Recent evidence regarding the healthcare resource utilization (HCRU) and associated costs of acromegaly is limited. Materials & methods: This retrospective, cross-sectional administrative claims analysis (IQVIA Pharmetrics Plus R ? ) identified patients (≥18 years) with acromegaly between 1 January 2017 and 30 June 2022. HCRU and costs over 1 year were compared in patients with acromegaly and matched patients without acromegaly (age, sex, insurance type, year). Among patients with acromegaly, annual total healthcare costs of comorbidities and procedures consistent with high-risk comorbidities were reported. Costs were adjusted to 2023 USD. Results: Among 2289 patients with acromegaly and 2289 matched patients without acromegaly, mean age was 49.8 years and 51.6% were female. Patients with acromegaly had a significantly (p Conclusion: Patients with acromegaly had higher HCRU and costs than matched patients without acromegaly, and the presence of acromegaly with high-risk comorbidities was associated with a substantial HCRU and cost burden. This high burden of illness may be alleviated with better disease control.