BMP signaling pathway

The bone morphogenetic protein (BMP) signalling pathway play critical roles in germ layer induction and patterning in early zebrafish embryos. Smad2/3 and Smad1/5/8 are intracellular effectors of BMPs. These Smads regulate, in cooperation with other factors, transcription of hundreds of target genes in the nucleus. The activity and stability of Smads are regulated by phosphorylation modifications.

骨形态发生蛋白（BMP）信号通路在早期斑马鱼胚胎的胚层诱导和模式形成中发挥着至关重要的作用。Smad2/3 和 Smad1/5/8 是 BMP 的细胞内效应因子。这些 Smads 与其他因素协同作用，调节核内数百个靶基因的转录。Smads 的活性和稳定性通过磷酸化修饰进行调控。