Gene expression profiling of mir-1825 alteration in Head and neck squamous cell carcinomas

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignant cancer worldwide. To understand the pathogenesis of HNSCC, we investigated the effects of miR-1825 overexpression on tumor formation capacity of head and neck cancer cells in vivo using NUDE mice. We searched for potential targets of miR-1828 using microarray analysis and luciferase assay. We found that miR-1825 expression is upregulated in head and neck cells and clinical tumor samples in comparison to corresponding controls, where it potentially acts as an oncogene. Gene expression microarray analyses were performed on FGFR1 KO K19-tva/fgfr1loxP/loxP mice and control K19-tva mice.