"Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis", CFTR interactomes

A tidy selection of published CFTR interactomes (or CFTR-related omics datasets)

Collects data from the original online sources, converts gene/protein identifiers into a standard tidy format and updates the identifiers. The Uniprot ID is taken as reference and all other identifiers are genereated from them. This causes some datasets to end up with less genes/proteins than reported.

Datasets included

Botelho (2021) - CFTR traffic regulators

Botelho et al (2022), submitted

Pankow (2015) - CFTR interactome

Pankow et al (2015) deltaF508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 528, 510--516. https://doi.org/10.1038/nature15729

Canato (2018) - CFTR interactome

Canato et al (2018) Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation. Cell Mol Life Sci. 75(24):4495-4509. https://doi.org/10.1007/s00018-018-2896-7

Santos (2019) - CFTR interactome

Santos et al (2019) Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum. Cells. 8(4):353. https://doi.org/10.3390/cells8040353

Hutt (2018) - CFTR interactome

Hutt et al (2018) A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease. J Mol Biol. 430: 2951-2973. https://doi.org/10.1016/j.jmb.2018.06.017

Rauniyar (2014) - CFTR proteome

Rauniyar et al (2014) Quantitative Proteomic Profiling Reveals Differentially Regulated Proteins in Cystic Fibrosis Cells. J Proteome Res. 13(11): 4668-4675. https://doi.org/10.1021/pr500370g

Almaça (2013) - ENaC regulome

Almaça et al (2013) High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets. Cell. 154(6):1390-400. https://doi.org/10.1016/j.cell.2013.08.045

Tomati (2018) - CFTR regulome

Tomati et al (2018) High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel. J Biol Chem. 293(4):1203-1217. https://doi.org/10.1074/jbc.m117.816595

Simpson (2012) - Secretome

Simpson et al (2012) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nature Cell Biology. 14, 764-774. https://doi.org/10.1038/ncb2510

Wang (2006) - CFTR interactome

Wang et al (2006) Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis. Cell. 127(4):803-815. https://doi.org/10.1016/j.cell.2006.09.043

Reilly (2017) - CFTR interactome

Reilly et al (2017) Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis. Sci Rep. 9;7(1):7642. https://doi.org/10.1038/s41598-017-06588-z

Gilchrist (2006) - Secretome

Gilchrist et al (2006) Quantitative Proteomics Analysis of the Secretory Pathway. Cell. 127(6):1265-1281. https://doi.org/10.1016/j.cell.2006.10.036

Pankow (2019) - CFTR interactome

Pankow et al (2019) A posttranslational modification code for CFTR maturation is altered in cystic fibrosis. Science Signaling. 12(562):eaan7984. https://doi.org/10.1126/scisignal.aan7984

Dang (2020) - CF lung disease modifier genes

Dang et al (2020) Mining GWAS and eQTL data for CF lung disease modifiers by gene expression imputation. PLoS One. 15(11):e0239189. https://doi.org/10.1371/journal.pone.0239189

Hodos (2020) - CF genomic meta-analysis

Hodos et al (2020) Integrative genomic meta-analysis reveals novel molecular insights into cystic fibrosis and deltaF508-CFTR rescue. Sci Rep 10(1):20553. http://dx.doi.org/10.1038/s41598-020-76347-0