ePath

ePath (essential genes in Pathway) database provides information for essential gene prediction in bacteria. In ePath, gene essentiality is linked to biological functions annotated by KEGG Ortholog. The overall goal of ePath is to provide a comprehensive and reliable reference for gene essentiality annotation, facilitating the study of those prokaryotes without experimentally derived gene essentiality information.ePath数据库（essential genes in Pathway，通路必需基因）可为细菌的必需基因预测提供相关支撑信息。在该数据库中，基因必需性与通过KEGG直系同源基因（KEGG Ortholog）注释的生物学功能直接关联，其总体目标是为基因必需性注释提供全面且可靠的参考依据，助力尚无实验验证基因必需性信息的原核生物相关研究。

搜集汇总

背景与挑战

背景概述

ePath数据库是一个专注于细菌必需基因预测的资源，通过KEGG Ortholog注释关联基因必需性与生物功能。它涵盖超过4000个原核生物基因组，适用于具有KEGG Ortholog编号且基因组完全测序的微生物，为缺乏实验数据的原核生物研究提供参考。