Domino Aryne Annulation via a Nucleophilic–Ene Process
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic–ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.
创建时间：
2018-02-12
