Management of Alopecia with Topical JAK Inhibitor Therapy: An Evidence-Based Review

Alopecia areata (AA) is a genetic, immune-mediated disease targeting hair follicles resulting in patches of hair loss, loss of all scalp hair (alopecia totalis), body hair (alopecia universalis). AA affects up to 2% of the general population. The use of topical Janus kinase inhibitors (JAKi) for AA remains experimental without consensus on their treatment efficacy. This systematic review examines the literature for outcomes using topical JAKi therapies in AA.