Plasma Proteomic analysis of Large Vessel Vasculitis

Takayasu arteritis (TAK) and giant cell arteritis (GCA) are the primary forms of large vessel vasculitis (LVV) and can result in serious cardiovascular morbidity. Improved understanding of the molecular basis of these diseases is required to develop novel biomarkers and targeted treatments.To address this, we performed plasma proteomic profiling using the Olink Inflammation 1 and Cardiometabolic Target panels to quantify 184 plasma proteins in two independent cohorts totalling 405 individuals. Cohort 1 included 96 patients with TAK, 35 patients with large vessel-GCA (LV-GCA) and 35 healthy controls (HCs). Cohort 2 consisted of patients presenting acutely with possible cranial GCA (C-GCA); C-GCA was subsequently confirmed (n=150) or excluded (Not C-GCA, n=89). The included datasets provide the scaled relative abundance measurements for both cohorts. The corresponding manuscript is currently under review for publication.