Number of positive responses out of 3 visits.

Table 4 is showing the number of positive subjects with detectable P1-specific antibodies for each scheduled visit, based on ΔΔCT values (ΔCT from immune-ΔCT baseline = ΔΔCT value; Positive if >1.996). Table5 is indicating the number of positive P1-specific responses out of the three scheduled medical visits. Number of subjects per treatment group that has completed the study is indicated in parenthesis and the corresponding percentage value is indicated. Immune vaginal samples were collected at week 17 (1 week after 3rd injection), week 25 (1 week after 4th injection) and week 29 (5 weeks after 4th injection). Immune rectal samples were collected at week 25. From visit to visit, the same subject can be positive or negative for the detection of mucosal antibodies, which renders difficult the data interpretation, as opposed to serum antibodies that remain stable over time.