Salamander.

CV for I(tpeak) and Iarea by the FSR, TWS and GWS models. CVs computed for the WT and the following virtual conditions. LIN: i.e., the nonlinear fluxes Eqs 10–12 were linearized. NLD (non-local depletion): in the product [E*]σ[cGMP] in the last term on the right hand side of Eq 9, [cGMP] was kept constant at its dark value. LIN+NLD: both effects were enforced. Ca2+-clamp: Ca2+ dependence of cyclase activity was removed, i.e., in the expression of F in Eq 10, [Ca2+] was kept at its dark value [Ca2+]dark. In all cases and for FSR and and for TWS and GWS. The CVs of E* for all models converge to identical values with larger sample number.