Expression data of A172 cell line treated with DMSO or Ch-M'

Glioblastoma is the most common adult brain tumour, representing a high degree of malignancy. It is reported that transcription factors are involved in the malignancy of glioblastoma , and RUNX1 is one of them. A novel gene switch-off agent, Chb-M', which is alkylating agent-conjugated pyrrole-imidazole polyamides, designed to fit the RUNX1 DNA groove, inhibits transcription of RUNX1. We We examined changes in the expression of downstream genes due to transcriptional inhibition of this agent. A172, a glioblastoma cell line, was treated with DMSO in the control group and Chb-M' (1µM), a transcriptional inhibitor of RUNX1, for 48 hours each, and the downstream gene changes were compared.