Human Bcl-2/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746

Human Bcl-2/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746 Descriptor: DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide Authors: Baird, J, Holliday, M. Deposit date: 2024-02-05 Release date: 2024-10-02 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting with Mass Spectrometry Collectively Discriminate the Binding of Small-Molecule Therapeutics to Bcl-2. Anal.Chem., 97, 2025