Supplementary information files for Ethnic differences in the association between age at natural menopause and risk of type 2 diabetes mellitus among postmenopausal women: a pooled analysis of individual data from 13 cohort studies

Supplementary files for article Ethnic differences in the association between age at natural menopause and risk of type 2 diabetes mellitus among postmenopausal women: a pooled analysis of individual data from 13 cohort studiesObjective: To investigate associations between age at natural menopause, particularly premature ovarian insufficiency (POI; natural menopause before 40 years), and incident type 2 diabetes (T2DM) and identify any variations by ethnicity.Research design and methods: We pooled individual-level data of 338,059 women from 13 cohort studies without T2DM before menopause, with six ethnic groups: White (n=177,674), Chinese (n=146,008), Japanese (n=9,061), South/Southeast Asian (n=2,228), Black (n=1,838), and Mixed/Other (n=1,250). Hazard ratios (HRs) of T2DM associated with age at menopause were estimated in the overall sample and by ethnicity, with study as a random effect. For each ethnic group, we further stratified the association by birth year, education level, and BMI.Results: Over nine years of follow-up, 20,064 (5.9%) women developed T2DM. Overall, POI (vs menopause at 50-51 years) was associated with an increased risk of T2DM (HR:1.31, 1.20-1.44), while there was an interaction between age at menopause and ethnicity (p

补充文件：关于绝经年龄与绝经后女性2型糖尿病风险关联的种族差异：13项队列研究个体数据的荟萃分析
研究目的：旨在探究自然绝经年龄（尤其是早发性卵巢功能不全[POI；绝经年龄在40岁之前]）与2型糖尿病（T2DM）新发病例之间的关联，并识别任何种族差异。研究设计与方法：我们将13项队列研究中的338,059名无T2DM病史的绝经前女性的个体水平数据进行荟萃分析，涉及六个种族群体：白人（n=177,674）、华人（n=146,008）、日本人（n=9,061）、南亚/东南亚人（n=2,228）、黑人（n=1,838）和混血/其他（n=1,250）。在总体样本和按种族划分的样本中，通过将研究作为随机效应来估计与绝经年龄相关的T2DM的危度比（HRs）。对于每个种族群体，我们还根据出生年份、教育水平和BMI对关联进行了分层。研究结果：在超过九年的随访期间，20,064（5.9%）名女性发展为T2DM。总体而言，POI（与50-51岁绝经相比）与T2DM的风险增加相关（HR：1.31，95%置信区间：1.20-1.44），同时绝经年龄与种族之间存在交互作用（p