IL6/Adiponectin/HMGB1 feedback loop mediates adipocyte and macrophage crosstalk and M2 polarization after myocardial infarction

Border zone differences contributed to different outcomes post-infarction, such as left ventricular aneurysm (LVA) and myocardial infarction (MI). LVA usually forms within 24 hours after the onset of MI and is prone to heart rupture, however, it is best performed three months after MI. Less research focused on the investigation of the LVA model, the differences of border zones on LVA and MI, and the mechanism in the border zone. LVA, MI and SHAM mice model was induced. We collected border zones of LVA, MI and SHAM heart samples at 7d post-infarction. RNA-seq was performed and differentially expressed genes were obtained to investigate the mechanism of LVA formation and MI progression.